Figure 2. Extension of yeast CLS by mutations predicted to phenocopy the cellular consequences of Meth-R.

(A) Effect of tRNA hypomethylation on CLS, (B) Effect of cytochrome C deficiency on CLS, dependent on the retrograde response, (C) Effect of cytochrome C overexpression on CLS, as compared with control cells (vector only), (D) Deletion of yeast metacaspase does not extend CLS. For all panels, bars denote SEM.