Table 1.

Animal and human studies using BMSCs for periodontal regeneration

Authors	Species	Cell source & carrier	Defect type	Effect
De Kok et al., 2003	Canine	BMSCs+HA/TCP	Alveolar saddle defect	Increased bone regeneration
Kawaguchi et al., 2004	Canine	BMSCs + collagen gel	Experimental ClassIII furcation defect	More periodontal regeneration
De Kok et al., 2005	Canine	BMSCs+HA/TCP	Extraction socket	BMSCs remained and contributed to bone regeneration.
Hasegawa et al., 2006	Canine	BMSCs + atelocollagen	Experimental ClassIII periodontal defect	Enhancement of periodontal tissue regeneration
Ito et al., 2006	Canine	BMSCs + fibrin & PRP	Peri-implant defect (circumferential type)	Increased bone regeneration & bone implant contact (BIC)
Pieri et al., 2008	Swine	BMSCs + PRP & luorohydroxyapatite FHA)	Sinus augmentation	Increased bone formation & BIC
Sun et al., 2008	Rabbit	BMSCs + inorganic material	Sinus augmentation	Increased new bone formation
Shayesteh et al., 2008	Human	BMSCs + HA/TCP	Sinus augmentation	41.34% New bone formation, no control
McAllister et al., 2009	Human	BMSCs + allograft	Sinus augmentation	High percentage of vital bone content, after a relatively short healing phase, no control
Pieri et al., 2009	Minipig	BMSCs + PRP & FHA	Alveolar defect (3.5 mm diameter and 8 mm depth)	Addition of MSCs to PRP-FHA enhances bone formation