Table 2.

Summary of Studies with 5-HT_1A Receptor Active Drugs on Sexual Behavior

Drug	Receptor	Action	Route	Behavior Examined	Effect	References
8-OH-DPAT	5-HT1A	agonist	peripheral	lordosis	decrease	(Fernandez-Guasti et al., 1987; Hebert et al., 1995; Snoeren et al., 2010; Snoeren et al., 2009; Snoeren et al., 2011b)
ipsapirone	5-HT1A	agonist	peripheral- hi dose	lordosis	decrease	(Mendelson and Gorzalka, 1986)
ipsapirone	5-HT1A	agonist	peripheral- low dose	lordosis	increase	(Mendelson and Gorzalka, 1986)
gepirone	5-HT1A	agonist	peripheral- hi dose	lordosis	decrease	(Mendelson and Gorzalka, 1986)
gepirone	5-HT1A	agonist	peripheral- low dose	lordosis	increase	(Mendelson and Gorzalka, 1986)
buspirone	5-HT1A	agonist	peripheral- hi dose	lordosis	decrease	(Mendelson and Gorzalka, 1986)
buspirone	5-HT1A	agonist	peripheral- low dose	lordosis	increase	(Mendelson and Gorzalka, 1986)
WAY 100635	5-HT1A	antagonist	peripheral	lordosis	increase	(Kishitake and Yamanouchi, 2004)
8-OH-DPAT	5-HT1A	agonist	ic-hypothalamus	lordosis	decrease	(Gonzalez et al., 1997; Uphouse et al., 1992b)
WAY 100135	5-HT1A	antagonist	ica-hypothalamus	lordosis	increase	(Uphouse et al., 1996a)
8-OH-DPAT	5-HT1A	agonist	ic-PAGb	lordosis	decrease	(Uphouse et al., 1992a)
8-OH-DPAT	5-HT1A	agonist	ic-POAc	lordosis	modest decrease	(Gonzalez et al., 1997; Uphouse and Caldarola- Pastuszka, 1993; Uphouse et al., 1992b)
8-OH-DPAT	5-HT1A	agonist	ic-POA-AHd	lordosis- hamsters	decrease	(Caldwell and Albers, 2002)
8-OH-DPAT	5-HT1A	agonist	ic-DRNe	lordosis	no effect	(Uphouse et al., 1992a)
8-OH-DPAT	5-HT1A	agonist	ic-MRNf	lordosis	decrease	(Uphouse et al., 1994)
buspirone	5-HT1A	agonist	ic-hypothalamus	lordosis	decrease	(Uphouse et al., 1992b)
5-OH-DPAC	5-HT1A	agonist	ic-hypothalamus	lordosis	decrease	(Uphouse et al., 1993)
5-MEO-DPAC	5-HT1A	agonist	ic-hypothalamus	lordosis	decrease	(Uphouse et al., 1993)
8-OH-DPAT	5-HT1A	agonist	peripheral	pacing time with male	decrease	(Snoeren et al., 2010)

^aic-intracranial;

^bPAG-periaqueductal gray;

^cPOA-preoptic area;

^dAH-anterior hypothalamus;

^eDRN-dorsal raphe;

^fMRN-median raph