Table 1. Association of common fragile sites with PEB-BLOCs and FANCD2 binding.

Selection of fragile sites*	Enriched regions	# of known common fragile sites	# of overlaps (enriched regions/FRA)	Permutation test (FRA to enriched regions)
				P-value	Lower tail
FRA , in epithelial cells from [50]	BRD4 binding (HPV1 E2)	44	43/19	0.032	TRUE
	FANCD2 binding		55/30	0.002	TRUE
FRA , cloned from [51]	BRD4 binding (HPV1 E2)	20	9/6	0.056	TRUE
	FANCD2 binding		16/10	0.030	TRUE
FRA , cervical cancer from [25]	BRD4 binding (HPV1 E2)	18	9/6	0.058	TRUE
	FANCD2 binding		16/10	0.032	TRUE

*Sites are listed in Table S6.

FRA: fragile sites.

TRUE: when the ‘Lower tail’ is TRUE it indicates that the absolute distances between FRA and enriched binding regions are consistent and small.