Figure 3. Mice with genetically-inactivated dopamine receptors displayed altered lengths of striatal neuronal cilia.

Eight-week-old D1-null mice, D2-null mice and their wild-type littermates on the C57BL/6J background were treated for 3 days with reserpine (3 mg/kg, s.c.) or vehicle. The average length of at least 200 neuronal cilia in the dorsolateral striatum from each of four mice in the respective groups was calculated; the data are means ± SEM of four average values per group (the wild-type groups contained two D1-littermates and two D2-littermates). The vehicle-treated D1-null and D2-null mice revealed significantly shorter and longer neuronal cilia, respectively, compared to the vehicle-treated wild-type controls (^# P<0.05). Reserpine-treated wild-type and D1-null mice, but not D2-null mice, displayed significantly longer neuronal cilia compared to vehicle-treated animals (*P<0.01).