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Expression of S229L Pol β induces chromosomal aberrations. Metaphase spreads of Pol β+/+ MEFs expressing either WT or S229L Pol β were analyzed for chromosomal aberrations. A, representative images of WT and S229L Pol β-expressing metaphase spreads. B, number of aberrations per metaphase. A total of at least 50 metaphases were scored for each cell line. *, **, and *** denote p < 0.05, 0.01, and 0.005, respectively.
