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. 2014 Mar 25;289(20):13717–13725. doi: 10.1074/jbc.M113.511030

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Biochemical and cellular IC₅₀ values for ML309. A, chemical structure of ML309. B, IDH1 R132H biochemical assay for (+)-ML309 (triangles) and (−)-ML309 (open squares). C, IDH1 R132C biochemical assay for (+)-ML309 (triangles) and (−)-ML309 (open squares). D, IDH1 WT biochemical assay for rac-ML309. E, cytotoxicity of U87MG IDH1 R132H cells for (+)-ML309 (triangles) and (−)-ML309 (open squares). Error bars are mean ± S.D. from two duplicate experiments. F, inhibition of 2-HG in U87MG IDH1 R132H cells for (+)-ML309 (triangles) and (−)-ML309 (open squares). Error bars are mean ± S.D. from two replicates.