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. 2014 Apr 1;289(20):13769–13781. doi: 10.1074/jbc.M114.549634

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Morphological and functional features of TSPO-null liver mitochondria. A, transmission electron microscopy of Tspo^loxP (left) and AlbCre;Tspo^loxP mouse livers (right); bar, 500 nm. B, oxygen consumption rate (OCR) of mitochondria of the indicated genotypes incubated with succinate plus rotenone (squares) or glutamate plus malate (circles). Where indicated, 4 mm ADP, 2.5 μg/ml oligomycin, 4 μm FCCP, and 2 μm antimycin plus 2 μm rotenone (circles only) were added. Error bars, mean ± S.D. C, typical recording traces of Rh123 fluorescence changes in Tspo^loxP (black trace) and AlbCre;Tspo^loxP (red trace) liver mitochondria. Where indicated, 0.5 mg/ml mitochondria, 5 mm succinate, and 0.5 μm FCCP were added. a.u., absorbance units.