TABLE 1.
Various metabolic parameters in the serum of WT and OSMRβ−/− mice under HFD conditions (n + 6–8)
In the fed states, mice were fasted for 4 h before the experiments to eliminate the feeding effect on lipid metabolism. In the fasted states, mice were fasted for overnight before the experiments. The data represent the mean ± S.E.
| Serum concentration | WT | OSMRβ−/− | OSMRβ−/−(PF) |
|---|---|---|---|
| Leptin (ng/ml) | 19.0 ± 2.2 | 25.7 ± 1.3a.b | 22.6 ± 1.8 |
| Serum amyloid A (ng/ml) | 26.9 ± 7.0 | 69.3 ± 15.8a | 46.8 ± 9.1c |
| TNF-α (pg/ml) | 5.80 ± 0.32 | 6.41 ± 0.23a | 6.13 ± 0.18 |
| IL-10 (pg/ml) | 11.7 ± 1.1 | 14.4 ± 0.5a | 12.9 ± 1.5 |
| Adiponectin (μg/ml) | 22.8 ± 0.1 | 22.9 ± 0.8 | 22.6 ± 1.8 |
| Glucose (fed) (mg/dl) | 163.7 ± 17.2 | 235.3 ± 8.3d | 203.8 ± 16.9c |
| Glucose (fasted) (mg/dl) | 119.3 ± 3.5 | 126.3 ± 1.9a | 125.8 ± 3.3c |
| Insulin (fed) (ng/ml) | 4.14 ± 1.42 | 42.0 ± 4.5a | 36.4 ± 6.2c |
| Insulin (fasted) (ng/ml) | 1.73 ± 2.81 | 20.0 ± 3.8a | 16.3 ± 8.2c |
| Total cholesterol (fed) (mg/dl) | 153.8 ± 11.6 | 200.3 ± 17.3a | 186.2 ± 19.6c |
| Total cholesterol (fasted) (mg/dl) | 70.0 ± 6.3 | 104.8 ± 7.7a | Not tested |
| Triglyceride (fed) (mg/dl) | 147.0 ± 12.6 | 175.5 ± 13.6a | 164.0 ± 6.4c |
| Triglyceride (fasted) (mg/dl) | 22.0 ± 1.9 | 36.0 ± 6.6a | Not tested |
| Free fatty acid (fed) (mmol/liter) | 1.76 ± 0.09 | 1.90 ± 0.13 | 1.90 ± 0.08 |
| Free fatty acid (fasted) (mmol/liter) | 0.75 ± 0.04 | 0.83 ± 0.05 | Not tested |
a p < 0.05 WT versus OSMRβ−/− mice, Student's t test.
b p < 0.05 OSMRβ−/− versus OSMRβ−/− (PF) mice, Student's t test.
c p < 0.05 WT versus OSMRβ−/− (PF) mice, Student's t test.
d p < 0.01 WT versus OSMRβ−/− mice, Student's t test.