FIGURE 5.

Schematic diagram of the heparin-induced GAPDH fibrillation pathway and its interaction with α-SN_oli. Heparin interacts with GAPDH inducing dissociation of tetramer into dimers, which then reassemble into the growing protofibril. The existence of additional potential intermediates (shadowed monomer and hexamer) is also proposed. The model of interaction between GAPDH protofibrils and α-SN_oli is based on the hydrophobic patch present at the edge of the protofibril allowing the recruitment α-SN_oli into a mixed protofibril.