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EA chimeras desensitize much more slowly than α7nAChR. Representative current traces show a 1.5-min agonist application to Xenopus oocytes injected with the indicated constructs. Acetylcholine at 100 μm was applied to α7nAChR; 30 mm cysteamine was applied to ELIC and EA chimeras. Rate constants for the initial rate of desensitization were calculated (n = 3): α7nAChR = 0.18 ± 0.05; ELIC = 2.4 ± 0.2; EAELIC = 1.6 ± 0.2; and EAα7 = 1.7 ± 0.2 min.
