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. 2014 Apr 9;289(20):14263–14271. doi: 10.1074/jbc.M114.561902

FIGURE 2.

FIGURE 2.

Loss of TBPH, the Drosophila Tdp-43 ortholog, increases miR-1 activity in fly wings. A, wings from control or dppGAL4::UAS-dmiR-1-expressing flies (dpp>dmiR-1) show that miR-1 expression causes decreased L3-L4 intervein distance (25). B, fly wings from intercrosses of three different TBPH hypomorphic lines to dpp>dmiR-1 flies showed enhancement of the dpp>dmiR-1 phenotype. Quantitation of wing phenotypes from parental, dpp>dmiR-1 (Control), or dpp>dmiR-1 X TBPH hypomorph crosses is shown. C, wing morphology in flies carrying the temperature-sensitive dpp>dmiR-1 allele housed at 18, 20, or 22 °C. Quantitation of wing phenotypes is shown. Narrow is defined as L3-L4 intervein distance of dpp>dmiR-1 at 18 °C; Enhanced Narrowing is defined as ≥50% further reduction in L3-L4 intervein distance as compared with dpp>dmiR-1 at 18 °C.