FIGURE 6.
Bloc1s8sdy/sdy and Bloc1s5mu/mu differentially affects the expression of NMDA receptor subunit transcripts. NMDA receptor subunit transcripts from adult wild type, Bloc1s8+/sdy, and Bloc1s8sdy/sdy mice hippocampi (A and B); Bloc1s5+/mu, and Bloc1s5mu/mu mice hippocampi (C and D) were analyzed by quantitative RT-PCR. A box plot depicts relative mRNA content with red boxes in A and C depicting single copy loss and red boxes in B and D depicting double copy loss alleles, respectively. Wild type is depicted in blue in all panels. Transcripts encoding the synaptic vesicle proteins VAMP2 and synaptophysin (Sphysin) were used as loading controls. Transcripts are listed to the left of graphs in italics (n = 3 animals with determinations in at least duplicate; one-way analysis of variance followed by Dunnett's multiple comparisons).