Table 3. MDMA-Related Mean (SEM) Self-Report Ratings Over the Entire Session, Calculated as Change from Pre-Capsule (Except End-of-Session).

	Drug condition
	Placebo		0.75 mg/kg MDMA		1.5 mg/kg MDMA
	Mean	SEM	Mean	SEM	Mean	SEM
Cardiovascular measures
Heart rate (b.p.m.)	−4.2	0.9	4.0	1.2a	11.1	2.2a,b
Systolic pressure (mm Hg)	3.6	1.1	8.4	1.4a	16.4	1.9a,b
Diastolic pressure (mm Hg)	3.1	0.9	7.0	1.2a	10.0	1.5a,b
Drug effects questionnaire
Feel drug	10.7	2.0	29.8	3.6a	45.5	4.5a,b
Feel high	8.6	1.8	28.6	3.6a	43.4	4.4a,b
Like drug	14.4	3.0	30.6	3.5a	40.1	4.3a,b
Dislike drug	9.6	2.8	13.1	2.7	20.1	3.3a,b
Want more	10.2	2.8	24.5	3.6a	33.8	4.3a,b
Visual analog scales
Anxious	−2.1	1.9	4.5	2.4a	12.1	3.2a,b
Confident	−3.7	1.6	1.7	2.2a	4.7	3.1a
Dizzy	2.3	1.3	8.4	2.4a	15.6	3.2a,b
Elated	1.2	1.7	13.1	2.6a	24.6	3.9a,b
Friendly	−4.5	1.6	2.6	2.5a	12.7	3.4a,b
Insightful	2.0	1.9	7.0	2.3a	17.8	3.4a,b
Lonely	0.4	1.3	3.4	1.9	9.6	3.0a,b
Loving	−0.7	1.6	5.6	2.3a	14.5	3.5a,b
Playful	−0.5	1.8	5.6	2.6a	15.1	3.8a,b
Restless	4.0	2.6	13.9	3.4a	23.4	4.1a,b
Sedated	4.7	2.6	5.0	3.5	5.2	3.2
Sociable	−2.6	1.9	4.4	2.7a	11.7	3.8a,b
Stimulated	3.0	2.1	16.5	3.1a	31.2	4.0a,b
End of session questionnaire
Take again	27.4	3.1	47.2	4.0a	61.8	(4.1)a,b

^aSignificantly different from placebo, P<0.001.

^bSignificantly different from 0.75 mg/kg, P<0.001.