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. 2014 Feb 12;39(7):1664–1673. doi: 10.1038/npp.2014.13

Figure 1.

Figure 1

Long-term object location memory (OLM) is impaired in BTBR mice. (a) Following handling and habituation, adult male C57BL/6 (B6) and BTBR mice were subjected to 5 min ‘training' during which two identical objects (A1 and A2) were placed in the corners of the apparatus. One day later, mice were tested for OLM ‘retention' : the same objects were used with one in the ‘familiar' location experienced during training (A3) and one placed in a ‘novel' location (A4). (b) Discrimination indices of the OLM retention trial show a robust difference between strains (values for individual mice plotted, line denotes the group mean±SEM; Mann-Whitney test, P<0.002; N⩾9/group). Despite the strain difference, a small subgroup of BTBR mice performed at the level of B6s. (c) Bar graph shows that mean exploration times (in seconds) were not different between strains on either the training (P=0.32) or retention (P=0.36) trial.