Figure 2.

Amelioration of alcohol withdrawal by ceftriaxone 200 mg/kg/day in alcohol-preferring (P) and Wistar rats. Stereotypy was almost completely eliminated by two-day ceftriaxone (200 mg/kg) treatment in P rats (a) and substantially reduced in Wistar rats (b) compared to saline-treated counterparts. Myoclonic body jerks were abolished in P rats (c) and diminished in Wistar rats (d) by ceftriaxone. Similarly, myoclonic head jerks were absent in ceftriaxone-treated P rats (e) and greatly reduced in Wistar rats (f) by ceftriaxone. (g) Ceftriaxone eliminated unprovoked startle responses in P rats, but (h) did not affect the relatively low frequency of spontaneous tonic/clonic seizures in Wistar rats. ^#P<0.05 by two-way ANOVA; *P<0.05 by Tukey posthoc test; n=6–10 per rat type. Data is expressed as mean±SEM.