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Ethanol withdrawal is associated with significant down regulation of the expression of EAAT2 in the striatum (a) One-way ANOVA followed by posthoc unpaired t-test (*P=0.002), and the mPFC (b) (*P=0.017). Two-day ceftriaxone (200 mg/kg) treatment upregulated EAAT2 protein levels in the striatum (a) (*P<0.05), but not in the mPFC (P>0.05), (b) of rats seven days following alcohol deprivation. Data is expressed as mean±SEM.
