Table 2.

35 selected meta-analyses (15 with binary outcomes and 19 with continuous outcomes)

Meta-analysis	Experimental intervention	Comparator	Binary outcome	Continuous outcome
1	Platform-switched implant restoration	Platform match	-	Marginal bone loss
2	Scaling and root planning + antimicrobial photodynamic therapy	Scaling and root planning	-	Clinical attachment level gain
3.	Low-level laser energy irradiation	Nonactive comparator	-	Trismus
4.a.	Coronally advanced flap + connective tissue graft	Coronally advanced flap	Complete root coverage	Gingival recession change
4.b.	Coronally advanced flap + enamel matrix derivative	Coronally advanced flap	Complete root coverage	Gingival recession change
4.c.	Coronally advanced flap + acellular dermal matrix	Coronally advanced flap	Complete root coverage	Gingival recession change
4.d.	Coronally advanced flap + barrier membranes	Coronally advanced flap + connective tissue graft	Complete root coverage	Gingival recession change
4.e	Coronally advanced flap + acellular dermal matrix	Coronally advanced flap + connective tissue graft	Complete root coverage	Gingival recession change
5.	Secondary closure technique	Primary closure technique	Infectious complication	Pain
6.a	Guided tissue regeneration (rm) + bone substitutes	Subepithelial connective tissue grafts	-	Gingival recession change
6.b	Guided tissue regeneration (rm) + bone substitutes	Guided tissue regeneration (rm)	Complete root coverage	Gingival recession change
7.	Platelet-rich plasma	Control	-	Clinical attachment level gain
8.a	Loading of osteointegreated implants within 1 week	Loading of osteointegreated implants after 2 months	Prosthesis failure	Marginal bone level changes
8.b	Loading of osteointegreated implants within 1 week	Loading of osteointegreated implants between 1 week and 2 months	Prosthesis failure	Marginal bone level changes
9.	Emdogain	Control	Probing attachment level gain < 2 mm	-
10.	Procedure with flap elevation	Flapless implant insertion	Implant failure	-
11.	1-stage bonding (self-etch)	2-stage bonding (acid-etch)	Bracket failure	-
12.	Dental floss	Interdental brushes	-	Interproximal gingival bleeding
13.	Antibiotic - Pre-operative prophylaxis	Placebo	-	Pain
14.	Glass-ionomer cement	Amalgam	Caries	-
15.a	Fluoride-containing resin-based sealant	Light-cured resin-based sealant	Complete retention	-
15.b	Rubber dam	Cotton rolls	Complete retention	-
16	Guided tissue regeneration	Control	-	Clinical attachment level gain
17.	Scaling and root planning + Diode laser	Scaling and root planning	-	Probing depth reduction
18.	Supplemental perioperative steroids	Placebo	-	Systolic blood pressure

rm: with resorbable membranes.