Table 1.
Association between eIF4E expression, integrin αvβ6 expression and clinicopathologic variables in colon cancer cases
| Clinicopathological factors | n | eIF4E expression | Value | Integrin αvβ6 expression | P Value | ||
|---|---|---|---|---|---|---|---|
| |
|
High (n = 74) |
Low (n = 64) |
|
Positive (n = 54) |
Negative (n = 84) |
|
| Gender |
|
|
|
0.345 |
|
|
0.927 |
| Male |
76 |
38 |
38 |
|
30 |
46 |
|
| Female |
62 |
36 |
26 |
|
24 |
38 |
|
| Age(years) |
|
|
|
0.874 |
|
|
0.108 |
| <60 |
70 |
38 |
32 |
|
32 |
38 |
|
| ≥60 |
68 |
36 |
32 |
|
22 |
46 |
|
| Tumor anatomical location |
|
|
|
0.634 |
|
|
0.773 |
| Right hemicolon cancer |
72 |
32 |
40 |
|
43 |
29 |
|
| Left hemicolon cancer |
66 |
32 |
34 |
|
41 |
25 |
|
| T stage |
|
|
|
0.072 |
|
|
0.011 |
| T1# |
1 |
0 |
1 |
|
0 |
1 |
|
| T2# |
13 |
8 |
5 |
|
2 |
11 |
|
| T3 |
55 |
23 |
32 |
|
17 |
38 |
|
| T4 |
69 |
43 |
26 |
|
35 |
34 |
|
| N stage |
|
|
|
0.067 |
|
|
0.109 |
| N0 |
76 |
34 |
42 |
|
26 |
50 |
|
| N1 |
44 |
28 |
16 |
|
17 |
27 |
|
| N2 |
18 |
12 |
6 |
|
11 |
7 |
|
| M stage |
|
|
|
|
|
|
|
| M0 |
114 |
57 |
57 |
0.063 |
40 |
74 |
0.034 |
| M1 |
24 |
17 |
7 |
|
14 |
10 |
|
| TNM stage |
|
|
|
0.009 |
|
|
0.012 |
| I - II |
72 |
31 |
41 |
|
21 |
51 |
|
| III-IV |
66 |
43 |
23 |
|
33 |
33 |
|
| Differentiation |
|
|
|
0.959 |
|
|
0.209 |
| Well |
50 |
26 |
24 |
|
15 |
35 |
|
| Moderate |
55 |
30 |
25 |
|
23 |
32 |
|
| Poor/undifferentiated |
33 |
18 |
15 |
|
16 |
17 |
|
| Survival (60-month follow-up) |
|
|
|
0.013* |
|
|
0.025* |
| Death |
63 |
40 |
23 |
|
30 |
33 |
|
| Censored | 75 | 34 | 41 | 24 | 51 | ||
Footnote: #Date of T1 and T2 were combined into one set for chi-square test.
*Log-rank test.