Table 3.
Univariate and multivariate analysis of association of clinicopathologic features with 5-year survival in colon cancer cases
|
Variable |
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| Relative risk | 95% CI | P Value | Relative risk | 95% CI | P Value | |
| Age at diagnosis |
1.091 |
1.063, 1.119 |
<0.001 |
1.114 |
1.083, 1.145 |
<0.001 |
| Gender |
|
|
|
|
|
|
| Male |
1.000(Ref.) |
- |
- |
|
|
|
| Female |
0.729 |
0.438, 1.212 |
0.223 |
|
|
|
| Tumor anatomical location |
|
|
|
|
|
|
| Right hemicolon cancer |
1.000(Ref.) |
- |
- |
|
|
|
| Left hemicolon cancer |
1.000 |
0.610,1.640 |
0.999 |
|
|
|
| T stage |
|
|
|
|
|
|
| T1 |
0.000 |
0.000, >105 |
0.973 |
|
|
|
| T2 |
0.951 |
0.395, 2.290 |
0.910 |
|
|
|
| T3 |
1.152 |
0.685, 1.937 |
0.595 |
|
|
|
| T4 |
1.000(Ref.) |
- |
- |
|
|
|
| N stage |
|
|
|
|
|
|
| N0 |
1.000(Ref.) |
- |
- |
|
|
|
| N1 |
1.308 |
0.760, 2.252 |
0.332 |
|
|
|
| N2 |
1.356 |
0.646, 2.843 |
0.421 |
|
|
|
| M stage |
|
|
|
|
|
|
| M0 |
1.000(Ref.) |
- |
- |
|
|
|
| M1 |
1.308 |
0.697, 2.454 |
0.403 |
|
|
|
| TNM stage |
|
|
|
|
|
|
| I |
1.000(Ref.) |
- |
- |
|
|
|
| II |
0.634 |
0.242, 1.664 |
0.355 |
|
|
|
| III |
0.998 |
0.378, 2.638 |
0.997 |
|
|
|
| IV |
1.029 |
0.362, 2.922 |
0.957 |
|
|
|
| Pathology Grade |
|
|
|
|
|
|
| Well |
1.000(Ref.) |
- |
- |
1.000(Ref.) |
- |
- |
| Moderate |
1.666 |
0.912, 3.046 |
0.097 |
1.348 |
0.721, 2.519 |
0.349 |
| Poor/undifferentiated |
1.845 |
0.950, 3.583 |
0.070 |
2.915 |
1.453, 5.848 |
0.003 |
| eIF4E |
|
|
|
|
|
|
| Low expression |
1.000(Ref.) |
- |
- |
1.000(Ref.) |
- |
- |
| High expression |
1.885 |
1.128, 3.150 |
0.016 |
2.417 |
1.413, 4.134 |
0.001 |
| αvβ6 |
|
|
|
|
|
|
| Negative |
1.000(Ref.) |
- |
- |
1.000(Ref.) |
- |
- |
| Positive | 1.741 | 1.061, 2.857 | 0.028 | 2.393 | 1.421, 4.028 | 0.001 |