Table 6.
The effects of SNP, DNA methylation, and their interactions in selected models ( IL4R )
| Model | Model frequency# | Parameter | Effects at age 10 (n = 34); Log-OR ( P value) | Effects at age 18 (n = 233); Log-OR ( P value $ ) | |
|---|---|---|---|---|---|
| 1 |
570 |
cg09791102 |
|
8.29 (0.53) |
−0.70 (0.2) |
| |
|
rs1110470 |
AA |
42.92 (0.33) |
−3.93 (0.6) |
| |
|
|
GG |
55.34 (0.24) |
−25.00 (0.004) |
| |
|
|
AG |
Ref. |
Ref. |
| |
|
cg09791102* rs1110470 |
AA |
−13.96 (0.34) |
1.42 (0.6) |
| |
|
|
GG |
−18.83 (0.23) |
8.51 (0.003) |
| |
|
|
AG |
Ref. |
Ref. |
| 2 |
546 |
cg09791102 |
|
−6.52 (0.18) |
3.27 (0.007) |
| |
|
rs1805011 |
AC |
−36.87 (1.00) |
16.62 (0.02) |
| |
|
|
CC |
22.14 (1.00) |
−5.22 (1.00) |
| |
|
|
AA |
Ref. |
Ref. |
| |
|
cg09791102* rs1805011 |
AC |
6.51 (1.00) |
−5.88 (0.02) |
| |
|
|
CC |
NA |
−3.27 (1.00) |
| |
|
|
AA |
Ref. |
Ref. |
| 3 |
571 |
cg09791102 |
|
−6.52 (0.18) |
3.34 (0.006) |
| |
|
rs1805012 |
AG |
−36.87 (1.00) |
17.16 (0.02) |
| |
|
|
GG |
22.14 (1.00) |
−5.01 (1.00) |
| |
|
|
AA |
Ref. |
Ref. |
| |
|
cg09791102* rs1805012 |
AG |
6.52 (1.00) |
−6.03 (0.02) |
| |
|
|
GG |
NA |
−3.34 (1.00) |
| |
|
|
AA |
Ref. |
Ref. |
| 4 |
633 |
cg26937798 |
|
−4.91 (0.23) |
1.53 (0.3) |
| |
|
rs3024685 |
AG |
22.65 (0.11) |
−24.15 (0.002) |
| |
|
|
GG |
−4.59 (1.00) |
0.62 (0.9) |
| |
|
|
AA |
Ref. |
Ref. |
| |
|
cg26937798* rs3024685 |
AG |
8.63 (0.11) |
−8.37 (0.003) |
| |
|
|
GG |
4.91 (1.00) |
0.09 (0.9) |
| |
|
|
AA |
Ref. |
Ref. |
| 5 |
761 |
cg26937798 |
|
0.01 (1.00) |
0.09 (0.9) |
| |
|
rs8832 |
AA |
−16.93 (1.00) |
10.38 (0.07) |
| |
|
|
GG |
−29.34 (0.59) |
−20.81 (0.01) |
| |
|
|
AG |
Ref. |
Ref. |
| |
|
cg26937798* rs8832 |
AA |
−0.01 (1.00) |
3.73 (0.09) |
| |
|
|
GG |
−11.56 (0.59) |
−7.23 (0.01) |
| AG | Ref. |
#The frequency is based on 1,000 bootstrap samples.
$P values significant at the 0.01 level at age 18 are in bold font.