Table 2. The effect of the 41 SNPs analyzed in our study on CAD in FH.
| SNP | proxy | Chr | Pos | RA | RAF | HR | 95% CI lower | 95% CI upper | P-value | Nearest gene | Genotyped/imputed |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs17464857 | 1 | 220829332 | G | 0.11 | 1.0339 | 0.57 | 1.50 | 0.89 | MIA3 | Imputed | |
| rs17114036 | 1 | 56735409 | G | 0.11 | 1.4222 | 0.98 | 1.86 | 0.11 | PPAP2B | Imputed | |
| rs11206510 | 1 | 55268627 | C | 0.17 | 1.0886 | 0.89 | 1.28 | 0.39 | PCSK9 | Genotyped | |
| rs602633 | 1 | 109623034 | T | 0.19 | 1.0458 | 0.85 | 1.24 | 0.66 | SORT1 | Genotyped | |
| rs4845625 | 1 | 152688691 | T | 0.44 | 1.0139 | 0.86 | 1.17 | 0.86 | IL6R | Genotyped | |
| rs6725887 | 2 | 203454130 | T | 0.14 | 1.2882 | 0.02 | 2.56 | 0.70 | WDR12 | Imputed | |
| rs515135 | 2 | 21139562 | T | 0.15 | 1.0793 | 0.86 | 1.30 | 0.50 | APOB | Imputed | |
| rs6544713 | 2 | 43927385 | T | 0.33 | 1.0643 | 0.90 | 1.22 | 0.45 | ABCG5-ABCG8 | Imputed | |
| rs1561198 | 2 | 85663500 | C | 0.46 | 0.9765 | 0.82 | 1.13 | 0.77 | VAMP5-VAMP8-GGCX | Imputed | |
| rs2252641 | 2 | 145517931 | T | 0.48 | 1.5015 | 1.03 | 1.97 | 0.10 | ZEB2-AC074093.1 | Imputed | |
| rs9818870 | 3 | 139604812 | T | 0.16 | 0.2871 | −1.55 | 2.13 | 0.18 | MRAS | Imputed | |
| rs1878406 | 4 | 148613114 | T | 0.15 | 0.8840 | 0.66 | 1.11 | 0.29 | EDNRA | Imputed | |
| rs7692387 | 4 | 156854759 | A | 0.2 | 0.0230 | −13.48 | 13.53 | 0.59 | GUCY1A3 | Imputed | |
| rs273909 | 5 | 131695252 | G | 0.15 | 0.8902 | 0.63 | 1.15 | 0.39 | SLC22A4-SLC22A5 | Imputed | |
| rs12205331 | rs12197124 | 6 | 35029419 | T | 0.21 | 0.6550 | 0.10 | 1.21 | 0.13 | ANKS1A | Imputed |
| rs10947789 | 6 | 39282900 | C | 0.22 | 0.0001 | −13.46 | 13.46 | 0.19 | KCNK5 | Imputed | |
| rs4252120 | 6 | 161063598 | C | 0.3 | 0.9838 | 0.83 | 1.14 | 0.84 | PLG | Imputed | |
| rs9369640 | rs7751826 | 6 | 12900977 | C | 0.37 | 0.9236 | −3.59 | 5.44 | 0.97 | PHACTR1 | Imputed |
| rs2048327 | 6 | 160783522 | T | 0.37 | 0.8940 | 0.73 | 1.06 | 0.18 | SLC22A3-LPAL2-LPA | Imputed | |
| rs12190287 | 6 | 134256218 | C | 0.38 | 1.0986 | 0.73 | 1.46 | 0.61 | TCF21 | Imputed | |
| rs2023938 | 7 | 19003300 | C | 0.12 | 1.1024 | 0.37 | 1.83 | 0.79 | HDAC9 | Imputed | |
| rs11556924 | 7 | 129450732 | C | 0.4 | 0.9822 | 0.83 | 1.14 | 0.82 | ZC3HC1 | Genotyped | |
| rs264 | 8 | 19857460 | G | 0.14 | 0.9500 | 0.72 | 1.18 | 0.66 | LPL | Genotyped | |
| rs2954029 | 8 | 126560154 | T | 0.45 | 0.9869 | 0.84 | 1.14 | 0.86 | TRIB1 | Genotyped | |
| rs579459 | 9 | 135143989 | C | 0.25 | 0.9838 | 0.81 | 1.16 | 0.85 | ABO | Imputed | |
| rs3217992 | 9 | 21993223 | C | 0.37 | 1.0781 | 0.93 | 1.23 | 0.33 | CDKN2BAS1 | Imputed | |
| rs12413409 | 10 | 104709086 | A | 0.07 | 1.0449 | 0.60 | 1.49 | 0.85 | CYP17A1-CNNM2-NT5C2 | Imputed | |
| rs2047009 | 10 | 43859919 | G | 0.44 | 0.9702 | −1.63 | 3.57 | 0.98 | CXCL12 | Imputed | |
| rs11203042 | 10 | 90979089 | T | 0.44 | 0.9130 | 0.76 | 1.06 | 0.24 | LIPA | Genotyped | |
| rs9326246 | 11 | 116116943 | C | 0.08 | 0.9456 | 0.64 | 1.25 | 0.72 | ZNF259-APOA5-APOA1 | Imputed | |
| rs974819 | 11 | 103165777 | T | 0.18 | 0.4280 | −0.58 | 1.44 | 0.11 | PDGFD | Imputed | |
| rs3184504 | 12 | 110368991 | C | 0.44 | 0.9943 | 0.84 | 1.15 | 0.94 | SH2B3 | Genotyped | |
| rs9515203 | 13 | 109847624 | C | 0.31 | 2.8507 | 0.67 | 5.03 | 0.34 | COL4A1-COL4A2 | Imputed | |
| rs9319428 | 13 | 27871621 | G | 0.33 | 1.0639 | 0.90 | 1.22 | 0.45 | FLT1 | Imputed | |
| rs7173743 | 15 | 76928839 | T | 0.45 | 0.9068 | 0.60 | 1.21 | 0.53 | ADAMTS7 | Imputed | |
| rs17514846 | 15 | 89217554 | C | 0.46 | 0.9977 | 0.85 | 1.15 | 0.98 | FURIN-FES | Genotyped | |
| rs2281727 | 17 | 2064695 | G | 0.32 | 1.0620 | 0.80 | 1.32 | 0.65 | SMG6 | Imputed | |
| rs12936587 | 17 | 17484447 | A | 0.47 | 1.0324 | 0.86 | 1.20 | 0.72 | RAI1-PEMT-RASD1 | Imputed | |
| rs15563 | 17 | 44360192 | G | 0.48 | 0.9946 | 0.85 | 1.14 | 0.94 | UBE2Z | Imputed | |
| rs1122608 | 19 | 11024601 | T | 0.21 | 0.7415 | 0.49 | 0.99 | 0.02 | LDLR | Imputed | |
| rs9982601 | 21 | 34520998 | C | 0.21 | 0.6858 | −1.43 | 2.80 | 0.73 | Gene desert (KCNE2) | Imputed |
Abbreviations: CAD, coronary artery disease; FH, familial hypercholesterolemia; SNPs, single-nucleotide polymorphisms.