Table II. Analysis of hematopoiesis in long-term marrow cultures of Nrf2−/− mice: weekly cobblestone number.
| Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | |
|---|---|---|---|---|---|
| Nrf2 −/− | 129.5±53.4 (n=4) | 327.0±101.3 (n=4) | 398.3±152.8 (n=4) | 1070.0±172.8 (n=4) | 1220.5±202.5 (n=4) |
| Nrf2 +/+ | 348.5±81.1 (n=4) | 941.0±122.7 (n=4) | 935.5±253.6 (n=4) | 1161.8±200.6 (n=4) | 1433.0±118.1 (n=4) |
| P | 0.0041 | 0.0002 | 0.0110 | 0.5142 | 0.1198 |
| Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | |
| Nrf2 −/− | 1001.0±157.2 (n=4) | 1016.8±135.2 (n=4) | 792.0±105.9 (n=4) | 580.3±166.4 (n=4) | 561.3±155.4 (n=4) |
| Nrf2 +/+ | 1303.0±200.2 (n=4) | 1042.3±207.6 (n=3) | 969.3±166.6 (n=3) | 557.0±162.2 (n=3) | 567.5±238.3 (n=2) |
| P | 0.0553 | 0.8498 | 0.1425 | 0.8607 | 0.9699 |
| Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | |
| Nrf2 −/− | 431.0±181.3 (n=4) | 415.5±219.8 (n=4) | 680.5±246.3 (n=4) | 399.8±135.0 (n=4) | 250.3±58.3 (n=4) |
| Nrf2 +/+ | 808.0±186.7 (n=2) | 671.0±. (n=1) | 478.5±. (n=1) | 272.0±. (n=1) | 525.0±. (n=1) |
| P | 0.0757 | ||||
| Week 16 | Week 17 | Week18 | Week 19 | Week 20 | |
| Nrf2 −/− | 594.0±293.5 (n=4) | 518.0±455.9 (n=4) | 278.0±235.4 (n=4) | 145.3±111.9 (n=4) | 148.8±182.0 (n=4) |
| Nrf2 +/+ | 429.0±. (n=1) | 313.0±. (n=1) | 206.0±. (n=1) | 118.0±. (n=1) | 44.0±. (n=1) |
| P | |||||
| Week 21 | Week 22 | Week 23 | Week 24 | Week25 | |
| Nrf2 −/− | 200.8±238.5 (n=4) | 176.8±220.8 (n=4) | 150.3±205.1 (n=4) | 184.3±318.8 (n=4) | 205.8±395.0 (n=4) |
| Nrf2 +/+ | 189.0±. (n=1) | 127.0±. (n=1) | 38.0±. (n=1) | 120.0±. (n=1) | 55.0±. (n=1) |
| P | |||||
| Week 26 | Week 27 | Week 28 | Week 29 | Week 30 | |
| Nrf2 −/− | 93.0±158.0 (n=4) | ||||
| Nrf2 +/+ | 118.0±. (n=1) | ||||
| P |
Data are summarized as mean±standard deviation, n is the number of mice used, and p-values were calculated with the two-sided two sample t-test. Significant p-values are shown in bold.