Table III. Analysis of hematopoiesis in long-term marrow cultures from Nrf2−/− mice: weekly non-adherent cell number.
| Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | |
|---|---|---|---|---|---|
| Nrf2 −/− | 17.81±1.55 (n=4) | 9.97±1.55 (n=4) | 8.08±0.31 (n=4) | 6.32±1.54 (n=4) | 6.98±0.82 (n=4) |
| Nrf2 +/+ | 22.22±1.28 (n=4) | 15.15±1.47 (n=4) | 12.44±1.60 (n=4) | 21.27±4.36 (n=4) | 16.34±2.55 (n=4) |
| P | 0.0047 | 0.0028 | 0.0106 | 0.0007 | 0.0004 |
| Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | |
| Nrf2 −/− | 6.01±0.89 (n=4) | 6.91±1.16 (n=4) | 5.91±1.48 (n=4) | 4.80±1.38 (n=4) | 1.87±2.24 (n=4) |
| Nrf2 +/+ | 9.92±1.86 (n=4) | 10.61±1.42 (n=3) | 8.45±0.82 (n=3) | 8.10±0.65 (n=3) | 7.15±2.89 (n=2) |
| P | 0.0090 | 0.0124 | 0.0452 | 0.0128 | 0.0655 |
| Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | |
| Nrf2 −/− | 3.09±0.37 (n=4) | 3.84±1.31 (n=4) | 3.79±2.19 (n=4) | 3.99±1.44 (n=4) | 3.84±1.01 (n=4) |
| Nrf2 +/+ | 7.51±0.81 (n=2) | 7.34±. (n=1) | 4.13±. (n=1) | 6.60±. (n=1) | 8.57±. (n=1) |
| P | 0.0006 | ||||
| Week 16 | Week 17 | Week18 | Week 19 | Week 20 | |
| Nrf2 −/− | 4.15±1.43 (n=4) | 4.36±1.85 (n=4) | 3.41±1.35 (n=4) | 2.66±1.13 (n=4) | 2.78±1.67 (n=4) |
| Nrf2 +/+ | 4.73±. (n=1) | 3.14±. (n=1) | 1.89±. (n=1) | 2.37±. (n=1) | 2.90±. (n=1) |
| P | |||||
| Week 21 | Week 22 | Week 23 | Week 24 | Week25 | |
| Nrf2 −/− | 3.35±2.54 (n=4) | 3.71±2.90 (n=4) | 3.16±1.79 (n=4) | 3.09±2.67 (n=4) | 2.81±2.47 (n=4) |
| Nrf2 +/+ | 3.57±. (n=1) | 2.04±. (n=1) | 2.05±. (n=1) | 2.05±. (n=1) | 2.46±. (n=1) |
| P | |||||
| Week 26 | Week 27 | Week 28 | Week 29 | Week 30 | |
| Nrf2 −/− | 2.70±1.76 (n=4) | ||||
| Nrf2 +/+ | 2.77±. (n=1) | ||||
| P |
Data are summarized as mean±standard deviation, n is the number of mice used, and p-values were calculated with the two-sided two sample t-test. Significant p-values are shown in bold. (×100000).