Table V. Analysis of hematopoiesis in long-term marrow cultures from Nrf2−/− mice: day 14 colony forming progenitor cell counts.
| Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | |
|---|---|---|---|---|---|
| Nrf2 −/− | 329.0±13.7 (n=3) | 146.7±8.6 (n=3) | 177.7±11.9 (n=3) | 300.7±6.5 (n=3) | 323.3±6.5 (n=3) |
| Nrf2 +/+ | 354.7±13.5 (n=3) | 288.7±9.3 (n=3) | 303.0±14.9 (n=3) | 204.7±16.3 (n=3) | 222.0±15.9 (n=3) |
| P | 0.0823 | <0.0001 | 0.0003 | 0.0007 | 0.0005 |
| Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | |
| Nrf2 −/− | 419.3±12.1 (n=3) | 227.3±6.5 (n=3) | 214.3±11.9 (n=3) | 217.0±8.2 (n=3) | 208.3±7.0 (n=3) |
| Nrf2 +/+ | 275.3±16.6 (n=3) | 172.0±8.0 (n=3) | 186.3±8.0 (n=3) | 179.7±6.5 (n=3) | 240.3±8.6 (n=3) |
| P | 0.0003 | 0.0007 | 0.0280 | 0.0035 | 0.0076 |
| Week 11 | Week 12 | Week 13 | Week 14 | Week 15 | |
| Nrf2 −/− | 138.0±6.0 (n=3) | 129.7±4.0 (n=3) | 103.0±9.2 (n=3) | 221.3±7.0 (n=3) | 193.0±12.1 (n=3) |
| Nrf2 +/+ | 146.0±6.0 (n=3) | 177.0±15.0 (n=3) | 114.0±11.1 (n=3) | 192.7±10.6 (n=3) | 224.7±11.0 (n=3) |
| P | 0.1778 | 0.0062 | 0.2570 | 0.0175 | 0.0286 |
| Week 16 | Week 17 | Week18 | Week 19 | Week 20 | |
| Nrf2 −/− | 82.0±5.6 (n=3) | 37.0±4.6 (n=3) | 87.3±6.1 (n=3) | 90.0±6.0 (n=3) | 47.0±4.6 (n=3) |
| Nrf2 +/+ | 182.3±10.6 (n=3) | 84.7±6.0 (n=3) | 58.3±6.0 (n=3) | 86.7±7.0 (n=3) | 109.7±10.0 (n=3) |
| P | 0.0001 | 0.0004 | 0.0043 | 0.5659 | 0.0006 |
| Week 21 | Week 22 | Week 23 | Week 24 | Week25 | |
| Nrf2 −/− | 48.7±3.2 (n=3) | 83.0±5.6 (n=3) | 74.0±4.0 (n=3) | 74.3±5.5 (n=3) | |
| Nrf2 +/+ | 50.0±4.0 (n=3) | 48.7±6.5 (n=3) | 95.0±4.0 (n=3) | 84.0±6.0 (n=3) | |
| P | 0.6760 | 0.0023 | 0.0030 | 0.1090 |
Data are summarized as mean±standard deviation, n is the number of observations, and p-values were calculated with the two-sided two sample t-test. Significant p-values are shown in bold.