TABLE 3. GO (Gene Ontology) Analysis of Genes Exhibiting Linearly Pb-Induced Methylation Changes (Hypermethylation and Hypomethylation) in Differentiating hESCs (Paradigm B in Fig. 1A).

Methylation status	GO category	p value
Hypermethylated	GO:0070509 Calcium ion import (4/32)	0.0008
Hypermethylated	GO:0090279 Regulation of calcium ion import (3/19)	0.002
Hypermethylated	GO:0048172 Regulation of short-term neuronal synaptic plasticity (2/7)	0.0036
Hypermethylated	GO:0031175 Neuron projection development (18/726)	0.009
Hypomethylated	GO:0030029 Actin filament-based process (50/488)	8.9E-06
Hypomethylated	GO:0030036 Actin cytoskeleton organization (46/437)	1.02E-05
Hypomethylated	GO:0070509 Calcium ion import (9/32)	3.31E-05
Hypomethylated	GO:0050877 Neurological system processes (93/1267)	0.0012