TABLE 4. Examples of Genes Exhibiting Pb-Induced Methylation Changes (GEE Analysis, See Methods) in Differentiating (Diff.) hESCs and NPC^0–19 (Paradigms B and C in Fig. 1A).

Cells	Cluster	Pb effect size	Pb effect standard error	p value	p adjusted	CpG sites/clusters	CpG sites	Genes	Methylation type	Gene location
Diff. hESCs	3227	−0.052	0.017	0.003	0.0127	5	cg17830308	NEUROG1	chr5:134870740–134872051	TSS1500
							cg11863728
							cg08451582
							cg02604503
							cg13336665
Diff. hESCs	5099	0.083	0.020	3.32E-05	0.0003	2	cg24469977	PLXNA4	non CpG	TSS200, 1st Exon
							cg24091954
Diff. hESCs	5842	−0.088	0.02	9.94E-06	8.59E-05	3	cg15833797	LHX3	chr9:139090420–139095472	Body
							cg21172615
							cg08967938
Diff. hESCs	10227	−0.136	0.028	1.54E-06	1.58E-05	2	cg15490703	EFNA2	chr19:1295513–1295891	Body
							cg22676470
Diff. hESCs	7121	−0.100	0.040	0.013	0.040498	5	cg25113360	GRIK4	non CpG	TSS1500TSS200
							cg24226238
							cg27179693
							cg10961484
							cg25316569
NPC0–19	6415	0.106	0.016	1.05E-10	5.8E-08	2	cg15490703	EFNA2	chr19:1295513–1295891	Body
							cg22676470
NPC0–19	4442	0.112	0.025	1.02E-05	0.0018	4	cg18247436	GRIK4	chr11:120856725–120857174	Body
							cg15174564
							cg24255125
							cg12122877
NPC0–19	3581	0.065	0.013	2.62E-07	0.00007	2	cg00522018	LHX3	Chr9:139090420–139095472	Body
							cg14381623