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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jun 6;33(8):1837–1843. doi: 10.1161/ATVBAHA.112.300752

Figure 6. Proposed mechanism by which estrogen inhibits VSMC proliferation via rapid, non-nuclear ER signaling.

Figure 6

Upon stimulation of estrogen, ERα interacts with and activates PP2A, and modulates activation of kinases induced by growth stimulation, leading to inhibition of VSMC proliferation.