Figure 2.

Schematic diagram shows the relationship between heat shock protein-27 (HSP27) and the androgen receptor (AR). Binding of Androgen (T) to AR causes a conformational change in the AR-HSP90/HSP70 complex in the cytoplasm. HSP27 undergoes a rapid phosphorylation and then it displaces HSP90 from the complex with AR. HSP27 chaperon AR from the cytoplasm into the nucleus. Once in the nucleus, the complex disassembles releasing AR, which binds to DNA where it facilitates transcription of DNA into mRNA.