Figure 6. RNA‐binding proteins (RBPs) contribute to isoform‐specific decay rates.

1. The presence of a PUF3 binding motif is associated with a sharp decrease in isoform stability. Decay rate (y‐axis) and distance from the annotated PUF3 binding site (x‐axis) for those genes with annotated PUF3 binding sites in their 3′UTRs are shown.
2. Isoform stabilities classified according to the presence (purple) or absence (green) of each of the 13 RBP motifs from (Riordan et al, 2011). The presence vs. absence of PUF3 motifs is associated with the greatest difference in isoform half‐lives.