Table 2.
Association of TF motifs with Nfib targets
| Motif | Gene | FC | p a c t | p r e p | MAS |
|---|---|---|---|---|---|
| NFIA_full |
Nfia |
2.27 |
<10-5 |
0.31 |
5.50 |
| NFIB_full |
Nfib |
*2.75 |
<10-5 |
0.27 |
5.12 |
| NFIX_full |
Nfix |
- |
<10-4 |
0.26 |
4.67 |
| Meis3_DBD_2 |
Meis3 |
NA |
<10-4 |
0.44 |
4.13 |
| MEIS3_DBD_2 |
Meis3 |
NA |
<10-4 |
0.44 |
4.03 |
| Meis2_DBD_2 |
Meis2 |
1.57 |
0.0001 |
0.53 |
3.98 |
| SNAI2_DBD |
Snai2 |
1.72 |
0.0002 |
0.86 |
3.78 |
| Rxra_DBD |
Rxra |
- |
0.0004 |
0.54 |
3.49 |
| EBF1_full |
Ebf1 |
- |
0.0004 |
0.46 |
3.49 |
| Rxrb_DBD |
Rxrb |
NA |
0.0004 |
0.69 |
3.49 |
| NR2F6_DBD_2 |
Nr2f6 |
- |
0.0004 |
0.75 |
3.46 |
| RXRA_DBD |
Rxra |
- |
0.0006 |
0.62 |
3.22 |
| NR2F1_DBD |
Nr2f1 |
1.83 |
0.0007 |
0.74 |
3.18 |
| RXRB_DBD |
Rxrb |
NA |
0.0007 |
0.41 |
3.16 |
| Pknox2_DBD |
Pknox2 |
- |
0.0009 |
0.41 |
3.05 |
| TFAP4_full |
Tfap4 |
NA |
0.0010 |
0.24 |
3.02 |
| PKNOX2_DBD |
Pknox2 |
- |
0.0010 |
0.60 |
3.00 |
| RXRG_DBD |
Rxrg |
NA |
0.0011 |
0.49 |
2.96 |
| NR2C2_DBD |
Nr2c2 |
- |
0.0012 |
0.65 |
2.93 |
| Nfib_MEME | Nfib | *2.75 | 0.0012 | 0.34 | 2.92 |
The table shows the TF motif name (motif), associated gene name (gene), expression fold-change (FC) of the gene, the (unadjusted) motif enrichment p-value in the activated set of genes (pact), the (unadjusted) motif enrichment p-value in the repressed set of genes (prep), and the motif association score (MAS). Rank is based on the magnitude of the MAS, “NA” indicates that no expression data is available for the TF gene and “-” in the FC column indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are derived from human TFs, others are from mouse TFs. *Although Nfib expression increases in the Nfib-KO, no functional protein is produced.