Table 4.

Regulatory targets of Nfib and Nr3c1 overlap significantly

	Activated	Repressed
Nfib	340	171
Nr3c1	117	143
Observed overlap	52	22
Expected overlap	4.0	2.5
Overlap fold enrichment	13.1	9.0
Overlap enrichment p-value	<10-46	<10-15

The table shows the sizes of the sets of activated and repressed genes for NFIB and GR, the size of the overlaps of the gene sets, the expected overlap size, fold enrichment of the overlap and the p-value of the overlap enrichment. Note that to compute the enrichment p-value, we must consider only the genes for which we have expression data for both knockouts (9990 genes), so the numbers of activated/repressed genes in this table are different than the numbers reported for the individual knockouts.