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. 2014 Mar 25;15:231. doi: 10.1186/1471-2164-15-231

Table 5.

Association of TF motifs with Nfib and Nr3c1 common targets

Rank Motif Gene FC N f i b FC N r 3 c 1 p a c t p r e p MAS
1
 AR_full
 Ar
 -
 -
 0.0013
 0.97
 2.86
2
 TBR1_full
 Tbr1
 NA
 -
 0.0016
 0.19
 2.79
3
 EBF1_full
 Ebf1
 -
 -
 0.0018
 0.89
 2.75
4
 TBX2_full_2
 Tbx2
 -
 -
 0.0020
 0.37
 2.71
5
 ZNF410_DBD
 Zfp410
 1.24
 -
 0.0025
 0.90
 2.60
6
 NR3C2_DBD
 Nr3c2
 -
 -
 0.0036
 0.82
 2.44
7
 Ar_DBD
 Ar
 -
 -
 0.0038
 0.93
 2.42
8
 NR3C1_DBD
 Nr3c1
 -
 *3.14
 0.0042
 0.84
 2.38
9
 TBX1_DBD
 Tbx1
 -
 -
 0.0048
 0.01
 2.32
10
 AR_DBD
 Ar
 -
 -
 0.0054
 0.75
 2.26
11
 EOMES_DBD
 Eomes
 NA
 -
 0.0057
 0.14
 2.24
12
 NFIB_full
 Nfib
 *2.75
 2.17
 0.0060
 0.13
 2.22
...
 ...
 ...
 ...
 ...
 ...
 ...
 ...
732
 ESRRB_DBD
 Esrrb
 NA
 1.31
 0.10
 0.0071
 -2.15
733
 MEF2A_DBD
 Mef2a
 0.72
 -
 0.91
 0.0060
 -2.22
734
 POU3F1_DBD_2
 Pouf3f1
 NA
 NA
 0.97
 0.0050
 -2.30
735
 ESRRG_full_3
 Esrrg
 -
 -
 0.14
 0.0038
 -2.42
736
 OTX1_DBD
 Otx1
 NA
 NA
 0.78
 0.0036
 -2.44
737
 Esrra_DBD_2
 Esrra
 NA
 NA
 0.03
 0.0008
 -3.10
738
 ESRRA_DBD
 Esrra
 NA
 NA
 0.13
 0.0005
 -3.26
739 FOXI1_full_2 Foxi1 NA - 0.62 <10-4 -4.01

The table shows the rank of the MAS score (rank), the motif name (motif), the associated gene name (gene), the expression fold-change (FC) of the gene in each KO, the (unadjusted) motif enrichment p-value in the activated set of genes (pact), the (unadjusted) motif enrichment p-value in the repressed set of genes (prep) and the motif association score (MAS). “NA” indicates that no expression data is available for the TF gene and “-” indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are for human TFs, others are for mouse TFs. *Note that these FC apply to the disrupted transcripts, and that no functional protein is produced for Nfib and Nr3c1.