Table 5.
Rank | Motif | Gene | FC N f i b | FC N r 3 c 1 | p a c t | p r e p | MAS |
---|---|---|---|---|---|---|---|
1 |
AR_full |
Ar |
- |
- |
0.0013 |
0.97 |
2.86 |
2 |
TBR1_full |
Tbr1 |
NA |
- |
0.0016 |
0.19 |
2.79 |
3 |
EBF1_full |
Ebf1 |
- |
- |
0.0018 |
0.89 |
2.75 |
4 |
TBX2_full_2 |
Tbx2 |
- |
- |
0.0020 |
0.37 |
2.71 |
5 |
ZNF410_DBD |
Zfp410 |
1.24 |
- |
0.0025 |
0.90 |
2.60 |
6 |
NR3C2_DBD |
Nr3c2 |
- |
- |
0.0036 |
0.82 |
2.44 |
7 |
Ar_DBD |
Ar |
- |
- |
0.0038 |
0.93 |
2.42 |
8 |
NR3C1_DBD |
Nr3c1 |
- |
*3.14 |
0.0042 |
0.84 |
2.38 |
9 |
TBX1_DBD |
Tbx1 |
- |
- |
0.0048 |
0.01 |
2.32 |
10 |
AR_DBD |
Ar |
- |
- |
0.0054 |
0.75 |
2.26 |
11 |
EOMES_DBD |
Eomes |
NA |
- |
0.0057 |
0.14 |
2.24 |
12 |
NFIB_full |
Nfib |
*2.75 |
2.17 |
0.0060 |
0.13 |
2.22 |
... |
... |
... |
... |
... |
... |
... |
... |
732 |
ESRRB_DBD |
Esrrb |
NA |
1.31 |
0.10 |
0.0071 |
-2.15 |
733 |
MEF2A_DBD |
Mef2a |
0.72 |
- |
0.91 |
0.0060 |
-2.22 |
734 |
POU3F1_DBD_2 |
Pouf3f1 |
NA |
NA |
0.97 |
0.0050 |
-2.30 |
735 |
ESRRG_full_3 |
Esrrg |
- |
- |
0.14 |
0.0038 |
-2.42 |
736 |
OTX1_DBD |
Otx1 |
NA |
NA |
0.78 |
0.0036 |
-2.44 |
737 |
Esrra_DBD_2 |
Esrra |
NA |
NA |
0.03 |
0.0008 |
-3.10 |
738 |
ESRRA_DBD |
Esrra |
NA |
NA |
0.13 |
0.0005 |
-3.26 |
739 | FOXI1_full_2 | Foxi1 | NA | - | 0.62 | <10-4 | -4.01 |
The table shows the rank of the MAS score (rank), the motif name (motif), the associated gene name (gene), the expression fold-change (FC) of the gene in each KO, the (unadjusted) motif enrichment p-value in the activated set of genes (pact), the (unadjusted) motif enrichment p-value in the repressed set of genes (prep) and the motif association score (MAS). “NA” indicates that no expression data is available for the TF gene and “-” indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are for human TFs, others are for mouse TFs. *Note that these FC apply to the disrupted transcripts, and that no functional protein is produced for Nfib and Nr3c1.