Table 3. List of top-ranked SNPs that interact with the APOE SNP rs7412 that were identified by CSE.
| Rank | SNP identifier | Chromosome number | Associated gene | Interaction score |
|---|---|---|---|---|
| 1 | rs7079348 | 10 | C10ORF11 | −833.573 |
| 2 | rs934745* | 18 | MAPK4 | −838.546 |
| 3 | rs10499687* | 7 | VWC2 | −840.237 |
| 4 | rs2517509 | 6 | MUC21 | −841.314 |
| 5 | rs2122339 | 2 | STIM2 | −841.828 |
| 6 | rs7817227 | 8 | C8orf80 | −843.664 |
| 7 | rs2779556* | 9 | GABBR2 | −845.716 |
| 8 | rs475093 | 1 | LOC440585 | −846.129 |
| 9 | rs17126808 | 8 | PSD3 | −849.232 |
| 10 | rs7585710 | 2 | ATP6V1C2 | −850.014 |
| 11 | rs7097398 | 10 | KIF20B | −854.823 |
| 12 | rs12162084 | 16 | HS3ST4 | −856.846 |
| 13 | rs473367 | 8 | POU5F1 | −857.432 |
| 14 | rs4394475 | 9 | NXNL2 | −857.973 |
| 15 | rs17330779 | 7 | NRCAM | −857.989 |
| 16 | rs17048904 | 4 | NDST4 | −858.782 |
| 17 | rs17151710 | 5 | CSNK1G3 | −858.302 |
| 18 | rs1763351 | 1 | COL11A1 | −859.012 |
| 19 | rs10824310 | 1 | PRKG1 | −859.285 |
Abbreviations: APOE, apoplipoprotein E; CSE, cuckoo search epistasis; SNP, single-nucleotide polymorphism.
Of the 19 SNPs in the table, 16 SNPs have been initially identified in both Reiman et al. (2007) and Li et al. (2008a). Three of the 19 SNPs (indicated by a star) have not been documented in previous studies and are potential candidates for future studies. The interaction score is the natural logarithm of the Bayesian score given in Equation 4.