Table 1.
The Helicobacter infected INS/GAS mouse model of Gastric Cancer
| Purpose of analysis | Results | Reference |
|---|---|---|
| H. pylori and H. felis and gastric mucosa | progression to gastric atrophy, metaplasia, dysplasia, and cancer | (Wang et al., 2000, Fox et al., 2003b, Fox et al., 2003a) |
| Gender differences | increased gastric carcinogenesis in males | (Fox et al., 2003a, Fox et al., 2003b) |
| Importance of CagE | loss of cagE temporally retards but does not abrogate cancer progression | (Fox et al., 2003b) |
| Interaction with G-Gly | G-gly synergizes with amidated gastrin to stimulate acid secretion and inhibits atrophy | (Cui et al., 2004) |
| CCK2R and Histamine receptor inhibitors | CCK2R and H2R antagonists synergistically inhibit gastric atrophy and cancer | (Takaishi et al., 2005) |
| Apoptosis of gastric epithelium | gastrin induces apoptosis and contribute to gastric carcinogenesis | (Cui et al., 2006, Przemeck et al., 2008) |
| TFF2 expression | TFF2 expression in the gastric fundus was elevated | (Tu et al., 2007) |
| Swedish variant of moist oral smokeless tobacco | tobacco promotes cancer formation | (Stenstrom et al., 2007) |
| Reg-1 expression | Reg1 is increased in the stomachs of H. felis-infected INS-GAS mice | (Steele et al., 2007) |
| Role of 17-beta-estradiol | 17beta-estradiol has protective effects on gastric cancer development | (Ohtani et al., 2007, Ohtani et al., 2011, Sheh et al., 2011) |
| Eradication of gastric Helicobacter spp. | eradication inhibits mouse gastric carcinogenesis | (Cai et al., 2005, Lee et al., 2008a, Lee et al., 2008b) |
| Commensal bacterial flora in the stomach | SPF mice are more susceptible to gastric cancer than germ-free mice | (Lofgren et al., 2011) |
| ASF restricted flora | restricted Altered Schaedler flora colonizes gastric niche and enhances gastric | (Lertpiriyapong et al., 2013) |
| High salt diet | high salt did not promote carcinogenesis | (Fox et al., 2003a) |
| Antral carcinogenesis | gastrin suppresses antral carcinogenesis | (Tomita et al., 2011, Takaishi et al., 2009) |
| H. felis-induced iron deficiency | marked changes in expression of gastric iron transporters and lowered systemic iron | (Thomson et al., 2012) |
| Folic acid supplementation | prevents gastric cancer | (Gonda et al., 2012) |