Table 2.
Iron depletion in gerbils increases the frequency and severity of gastric inflammation, dysplasia, and adenocarcinoma
| 2 weeks (n = 48) | 6 weeks (n = 58) | 12 weeks (n = 39) | ||||
|---|---|---|---|---|---|---|
| Iron-replete (n = 24) |
Iron-depleted (n = 24) |
Iron-replete (n = 29) |
Iron-depleted (n = 29) |
Iron-replete (n = 20) |
Iron-depleted (n = 19) |
|
| Gastritis | 3/24 (13%) | 8/24 (33%) | 16/29 (55%) | 23/29 (79%) | 18/20 (90%) | 18/19 (95%) |
| Dysplasia | 2/24 (8%) | 5/24 (21%) | 9/29 (31%) | 18/29 (62%)^ | 9/20 (45%) | 14/19 (74%) |
| Adenocarcinoma | 1/24 (4%) | 2/24 (8%) | 3/29 (10%) | 13/29 (45%)^ | 7/20 (35%) | 11/19 (58%) |
^
Statistical significance (P ≤ 0.05) was determined by χ2 tests comparing iron-depleted gerbils to iron-replete gerbils
(Reprinted with permissions (Noto et al., 2013))