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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Biol Psychiatry. 2013 Sep 5;75(2):96–104. doi: 10.1016/j.biopsych.2013.07.036

Figure 4.

Figure 4

Disruption of METH-associated memory by F-actin depolymerization does not depend on memory strength or type of learning. (A) Schematic of experimental design for LatA-induced disruption of METH-associated memory following a strong Pavlovian training protocol. (B) Intra-BLC LatA disrupts METH-associated memory following strong training (Vehicle n=11, LatA n=9). (C) Schematic of experimental design for context induced reinstatement of instrumental METH seeking. (D) Association between active lever with METH reinforcement in Context A and subsequent extinction of active lever pressing in Context B. (E) Intra-BLC LatA treatment prior to Reinstatement test 1 (R1) produces a persistent disruption of context-induced METH seeking (Vehicle n=9, LatA n=10). Error bars represent SEM.