Table 4. Odds ratios (95% confidence interval) associated with per 5‐mmol/L increase of plasma homocysteine in relation to fracture.

Independent variables	OR (95% CI)	P‐value
Homocysteine (per 5 mmol/L increase)	1.42 (1.12 –1.78)	0.013
Duration of diabetes (per 5‐year increase)	2.17 (1.11 –2.95)	0.025
HbA1c (per 1% increase)	1.21 (1.03 –1.52)	0.038
Urinary ACR (per 5‐mg/g increase)	0.67 (0.25 –1.01)	0.826
Serum creatinine (per 10‐μmol/L increase)	0.85 (0.54 –1.05)	0.641
Serum folate (per 10‐nmol/L increase)	0.82 (0.65 –1.03)	0.657
Serum B12 (per 100‐pmol/L increase)	0.98 (0.81 –1.08)	0.968

All values are the odds ratios (OR) and 95.0% confidence intervals (CI). Model Nagelkerke R² 0.26. Homocysteine was adjusted for duration of diabetes, glycated hemoglobin (HbA1c), urinary albumin to creatinine ratio (ACR), serum creatinine, serum folate and vitamin B₁₂.