Table 1. Connectivity Map analysis of leukemia CRGs.
The 72 gene LCRG signature was used to query the Broad Institute’s Connectivity Map (CMAP). The top 49 negatively correlated compounds are shown.
| Compound | Cell Type Assayed | Array | Connectivity Score (CS) |
|---|---|---|---|
| tyrphostin AG-825 | MCF7 | u133AofAAv2 | −1 |
| 4-hydroxy-2-nonenal | RKO | hgu133plus2.mas5 | −0.944695822 |
| rosiglitazone | HL60 | hgu133a | −0.849921146 |
| yohimbine | MCF7 | u133AofAAv2 | −0.833242887 |
| deferoxamine | PC3 | hgu133a | −0.810877648 |
| staurosporine | MCF7 | hgu133a | −0.784517747 |
| LY-294002 | MCF7 | u133AofAAv2 | −0.779534308 |
| thioridazine | MCF7 | hgu133a | −0.739939595 |
| exisulind | MCF7 | hgu133a | −0.736585969 |
| 4-hydroxy-2-nonenal | RKO | hgu133plus2.mas5 | −0.723096655 |
| cobalt chloride | MCF7 | hgu133a | −0.713366654 |
| NU-1025 | MCF7 | hgu133a | −0.698630633 |
| minocycline | MCF7 | u133AofAAv2 | −0.687270265 |
| LY-294002 | MCF7 | u133AofAAv2 | −0.670194206 |
| clozapine | MCF7 | hgu133a | −0.663687044 |
| 5224221 | MCF7 | u133AofAAv2 | −0.656678467 |
| trifluoperazine | MCF7 | hgu133a | −0.643054546 |
| carbamazepine | MCF7 | u133AofAAv2 | −0.632176605 |
| 5248896 | MCF7 | u133AofAAv2 | −0.631981557 |
| Ara-C | primaryAML1 | hgu133plus2 | −0.621453076 |
| TTNPB | MCF7 | hgu133a | −0.605754727 |
| 5252917 | MCF7 | u133AofAAv2 | −0.600199581 |
| fulvestrant | MCF7 | u133AofAAv2 | −0.596498871 |
| 5182598 | MCF7 | u133AofAAv2 | −0.569870646 |
| estradiol | MCF7 | u133AofAAv2 | −0.563035483 |
| doxycycline | MCF7 | u133AofAAv2 | −0.535758294 |
| trichostatin A | MCF7 | u133AofAAv2 | −0.531625057 |
| phenanthridinone | MCF7 | u133AofAAv2 | −0.525721398 |
| W-13 | MCF7 | hgu133a | −0.524775982 |
| ikarugamycin | MCF7 | u133AofAAv2 | −0.521146751 |
| raloxifene | MCF7 | hgu133a | −0.517786179 |
| tretinoin | HL60 | hgu133a | −0.516975031 |
| prazosin | MCF7 | u133AofAAv2 | −0.506939292 |
| phenyl biguanide | MCF7 | hgu133a | −0.49527295 |
| valproic acid | MCF7 | u133AofAAv2 | −0.493871119 |
| chlorpromazine | MCF7 | hgu133a | −0.487556832 |
| colchicine | MCF7 | hgu133a | −0.447879508 |
| monensin | MCF7 | u133AofAAv2 | −0.436030095 |
| genistein | PC3 | hgu133a | −0.430373293 |
| TTNPB | PC3 | hgu133a | −0.430033398 |
| tioguanine | MCF7 | hgu133a | −0.421921152 |
| trichostatin A | MCF7 | u133AofAAv2 | −0.418453342 |
| staurosporine | MCF7 | hgu133a | −0.409294748 |
| LY-294002 | SKMEL5 | hgu133a | −0.40882847 |
| phenformin | MCF7 | hgu133a | −0.396945788 |
| haloperidol | MCF7 | u133AofAAv2 | −0.372750449 |
| 17-allylamino-geldanamycin | SKMEL5 | hgu133a | −0.366981005 |
| valproic acid | MCF7 | u133AofAAv2 | −0.360150576 |
| fulvestrant | MCF7 | hgu133a | −0.315383178 |