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. Author manuscript; available in PMC: 2014 Jun 5.
Published in final edited form as: Nature. 2013 Dec 5;504(7478):113–118. doi: 10.1038/nature12823

Extended Data Figure 9. S1-S4 as a stationary domain.

Extended Data Figure 9

a, Superimposition of apo- and RTX/DkTx bound TRPV1 structures (orange and blue, respectively) from top-down view. S1-S4 domain (outlined in dashed box) shows near complete overlap. b, Same comparison for apo- and capsaicin bound channel structures (orange and green, respectively). c, d, Superimposition of transmembrane core of apo- versus RTX/DkTx- or capsaicin-bound TRPV1 structures (orange, blue, and green, respectively). Dashed box denotes region highlighted in Figure 6.