Table 2.

Presentation Style and Update frequency

Site	Search Style	Coloration and Graphics	Interaction Result Display	Last Update	Flesch-Kincaid Reading Level*
CVS	Type drug and supplement name	No	Bullet list with description and severity	9/4/01	N/A
Dr. Oz	Alphabetic list of supplements	No	Bullet list of drugs classes, no severity	Unknown	10.51
Medline Plus	Alphabetic list of supplements	No	List of drug classes and CYP450 substrates categorized by severity	07/14/12	23.55
Drugs.com	Type either drug or supplement, auto-suggest	Both	Detailed description, consumer or professional, severity presented in traffic sign icons	10/15/12	17.73
Vitamin Herb University	Select supplement from dropdown list	Both	“Caution” followed by interactions list by drug class, no severity	Unknown	17.46
Healthline.com	Type with auto-suggest or select from list, drug and supplement	Both	Severity, meter, coloration for specific drug-CAM pair	Unknown	14.12
Reference.medscape.com	Type with auto-suggest	Coloration	Severity colorized, short description for specific drug-CAM pair	Unknown	19.40

^*Scores over 22 should generally be taken to mean graduate level text.