Table 5.
Consistency between BRAF / cKIT / CyclinD1 alterations in paired samples from patients with multiple melanoma
| Tissue type | No. of cases |
Cases with consistent mutation patterns, n (%) |
|
|---|---|---|---|
| BRAF + cKIT + CyclinD1 alterations | BRAF mutations | ||
|
Subsequent vs. first primary melanoma | |||
|
Second melanoma |
107 |
53 (49.5) |
73 (68.2) |
|
Third/Fourth melanoma |
15 |
7 (46.7) |
9 (60.0) |
|
Subsequent vs. second primary melanoma | |||
|
Third/Fourth melanoma |
15 |
8 (53.3) |
11 (73.3) |
|
Multiple melanomas at the same anatomical site (head/neck - trunk - limbs) | |||
|
All cases |
48 |
25 (52.1) |
31 (64.6) |
| Synchronous |
13 |
7 (53.8) |
8 (61.5) |
| Asynchronous | 35 | 18 (51.4) | 23 (65.7) |