TABLE 2.
Synergy testing of amphotericin B and myriocin
| Strain | MICa (μg/ml) of AmB: |
FIC | MIC (μg/ml) of myriocin: |
FIC | FIC index | ||
|---|---|---|---|---|---|---|---|
| Only | With myriocin | Only | With AmB | ||||
| C. albicans (SC5314) | 0.063 | 0.016 | 0.250 | 2.0 | 0.063 | 0.032 | 0.282 |
| C. glabrata (CG462) | 0.125 | 0.016 | 0.125 | 1.0 | 0.125 | 0.125 | 0.250 |
| C. lusitaniae (CL6) | 0.250 | 0.063 | 0.250 | 4.0 | 0.250 | 0.063 | 0.313 |
| S. cerevisiae (FY4) | 0.125 | 0.032 | 0.250 | 1.0 | 0.063 | 0.063 | 0.313 |
a
MIC is defined as the concentration at which >95% of cells are killed. The synergy testing was done three times with comparable results.