TABLE 1.
Pharmacokinetics (mean) of a model of human therapy in rabbits
| PK parameter | Subject | Valuea |
|||
|---|---|---|---|---|---|
| Vancomycin | Linezolid | Clindamycin | Ceftaroline fosamil | ||
| Cmax (mg/liter) | Rabbit | 13.7 | 11 | 24 | |
| Human | 15.6 | 12 | 21 | ||
| Cmin (mg/liter) | Rabbit | 2.3 | 1.4 | 0.8 | |
| Human | 2.6 | 0.75 | 0.25 | ||
| Css (mg/liter) | Rabbit | 32.82 | |||
| Human | 30 | ||||
| AUC0-24 (mg · h/liter) | Rabbit | 382 | 122 | 99 | 166 |
| Human | 352 | 138 | 68 | 131 | |
a
Using vancomycin in continuous infusion (equivalent to a CSS of 30 mg/liter for 48 h), linezolid (equivalent to 600 mg i.v. twice daily for 48 h), clindamycin (equivalent to 600 mg i.v. 3 times daily for 48 h), or ceftaroline fosamil (equivalent to 600 mg i.v. twice daily for 48 h) (expressed as the total drug fraction).