TABLE 2.

Risk of incident tuberculosis in 13,431 cohort participants based on bivariable and multivariable Poisson regression analyses^a

Covariable	No previous ART (132 events during 41,891 PYFU)				Current ART (50 events during 65,657 PFYU)
	IRR bivariable models (95% CI)b	P value	IRR multivariable models (95% CI)	P value	IRR bivariable models (95% CI)b	P value	IRR multivariable models (95% CI)	P value
Cumulative co-trimoxazole use/yr	0.71 (0.56–0.90)	0.005	0.70 (0.55–0.89)	0.004	0.85 (0.72–1.00)	0.05	0.87 (0.74–1.0)	0.088
Square root CD4 cells/μl	0.90 (0.88–0.92)	<0.001	0.88 (0.86–0.90)	<0.001	0.85 (0.82–0.89)	<0.001	0.84 (0.80–0.87)	<0.001
Region of originc	3.4 (2.3–5.0)	<0.001	3.8 (2.5–5.7)	<0.001	5.5 (3.1–9.6)	<0.001	4.2 (2.3–7.6)	<0.001
IDU	1.1 (0.77–1.6)	0.625	1.4 (0.95–2.1)	0.092	0.31 (0.12–0.78)	0.013	0.46 (0.17–1.2)	0.113
Age of >40 yrd	0.71 (0.46–1.1)	0.117	0.85 (0.54–1.3)	0.480	0.54 (0.28–1.1)	0.074	0.61 (0.31–1.2)	0.155

^aAbbreviations: CI, confidence interval; IRR, incidence rate ratio; ART, antiretroviral treatment; IDU, intravenous drug use.

^bThe IRR bivariable models were adjusted for time-updated CD4 cell count.

^cRegion of origin other than Europe, North America, or Australia.

^dAge at baseline (1 January 1992 or at registration in the Swiss HIV Cohort Study, whichever is later).