TABLE 3.

All-cause mortality in 13,431 cohort participants based on bivariable and multivariable Poisson regression analyses^a

Covariable	No previous ART (1,769 events during 42,229 PYFU)				Current ART (678 events during 66,419 PYFU)
	IRR bivariable models (95% CI)b	P value	IRR multivariable models (95% CI)	P value	IRR bivariable models (95% CI)b	P value	IRR multivariable models (95% CI)	P value
Current co-trimoxazole use	0.05 (0.04–0.07)	<0.001	0.05 (0.04–0.07)	<0.001	0.18 (0.13–0.24)	<0.001	0.18 (0.13–0.23)	<0.001
Square root CD4 cells/μl	0.79 (0.79–0.80)	<0.001	0.78 (0.77–0.78)	<0.001	0.87 (0.86–0.88)	<0.001	0.84 (0.83–0.85)	<0.001
Region of originc	0.61 (0.50–0.76)	<0.001	0.65 (0.52–0.80)	<0.001	0.35 (0.26–0.48)	<0.001	0.48 (0.35–0.66)	0.001
IDU	1.1 (0.97–1.2)	0.154	1.1 (1.0–1.3)	0.013	1.9 (1.6–2.2)	<0.001	2.1 (1.8–2.5)	<0.001
Age of >40 yrd	1.4 (1.2–1.5)	<0.001	1.6 (1.4–1.7)	<0.001	1.6 (1.4–1.9)	<0.001	2.0 (1.7–2.3)	<0.001

^aAbbreviations: CI, confidence intervals; IRR, incidence rate ratio; ART, antiretroviral treatment; IDU, intravenous drug use.

^bThe IRR bivariable models were adjusted for time-updated CD4 cell count.

^cRegion of origin other than Europe, North America, or Australia.

^dAge at baseline (1 January 1992 or at registration in the Swiss HIV Cohort Study, whichever is later).