TABLE 1.
Main characteristics of Carba NP test, UV spectrophotometric method, and DNA microarray for the detection of carbapenemase-producing Enterobacteriaceae
| Test parameters | Detection method characteristics |
|||
|---|---|---|---|---|
| PCR + sequencing | Carba NP test | UV spectrophotometry | DNA microarray | |
| Efficiency (%)a | ||||
| Sensitivity | 100 | 100 | 100 | 98.8 |
| Specificity | 100 | 100 | 100 | 100 |
| PPV | 100 | 100 | 100 | 100 |
| NPV | 100 | 100 | 100 | 99.7 |
| Other characteristics | ||||
| Rapidity (h) | 24–48 | <2 | 12–24 | 8–24 |
| Costb | $$ | $ | $ | $$$ |
| Expertise needsc | ++ | + | +++ | ++ |
| Complete gene identificationd | + | − | − | +/− |
a
PPV, positive predictive value; NPV, negative predictive value.
b
The number of $'s correlates with the effective (relative) price of the test.
c
The number of +'s correlates with the expertise and training needed to perform and interpret the test.
d
The + means that the technique is able to give a complete gene identification, the − means that the technique is not able to give a complete gene identification, and the +/− means that the technique is able to give a partial gene identification.