TABLE 3.

Comparative in vitro activities of kibdelomycin, fidaxomicin, metronidazole, clindamycin, and moxifloxacin against members of the Bacteroides group

Organism (no. of isolates)	Antimicrobial agent	MIC (μg/ml)
		50%	90%	Range
Bacteroides caccae (10)	Kibdelomycin	32	>32	0.25–>32
	Fidaxomicin	>32	>32	>32–>32
	Metronidazole	0.5	1	0.25–1
	Clindamycin	8	>64	≤0.125–>64
	Moxifloxacin	16	>32	0.5–>32
Bacteroides distasonis (29)	Kibdelomycin	0.125	>32	0.03–>32
	Fidaxomicin	>32	>32	>32–>32
	Metronidazole	0.5	1	0.125–1
	Clindamycin	8	>64	1–>64
	Moxifloxacin	1	16	0.25–>32
Bacteroides eggerthii (30)	Kibdelomycin	>32	>32	0.125–>32
	Fidaxomicin	>32	>32	32–>32
	Metronidazole	0.5	1	0.5–1
	Clindamycin	4	>64	0.5–>64
	Moxifloxacin	4	>32	0.5–>32
Bacteroides fragilis (105)	Kibdelomycin	>32	>32	0.5–>32
	Fidaxomicin	>32	>32	32–>32
	Metronidazole	0.5	1	0.125–2
	Clindamycin	2	>64	≤0.125–>64
	Moxifloxacin	1	16	0.25–>32
Bacteroides ovatus (10)	Kibdelomycin	>32	>32	0.25–>32
	Fidaxomicin	>32	>32	>32–>32
	Metronidazole	0.5	1	0.25–1
	Clindamycin	4	>64	4–>64
	Moxifloxacin	4	16	2–32
Bacteroides thetaiotaomicron (59)	Kibdelomycin	>32	>32	0.25–>32
	Fidaxomicin	>32	>32	32–>32
	Metronidazole	1	1	0.015–2
	Clindamycin	8	>64	≤0.125–>64
	Moxifloxacin	4	32	0.25–>32
Bacteriodes uniformis (33)	Kibdelomycin	>32	>32	0.125–>32
	Fidaxomicin	>32	>32	>32–>32
	Metronidazole	1	1	0.25–1
	Clindamycin	8	>64	≤0.125–>64
	Moxifloxacin	8	>32	2–>32
Bacteriodes vulgatus (28)	Kibdelomycin	1	>32	0.125–>32
	Fidaxomicin	>32	>32	32–>32
	Metronidazole	0.5	1	0.125–1
	Clindamycin	16	>64	≤0.125–>64
	Moxifloxacin	32	>32	0.5–>32