TABLE 1.
In vitro IC50s of various galactofuranose derivatives for L. donovani promastigote growth and determination of CC50s toward human macrophages
| Compound | IC50 (μM)a (mean ± SEM) | CC50 (μM)a (mean ±SEM) |
Selectivity index (CC50/IC50) |
||
|---|---|---|---|---|---|
| HMØ | THP-1 | HMØ | THP-1 | ||
| 1 | 8.96 ± 2.5 | 1,431.4 ± 0.4 | 1,508.4 ± 0.03 | 159.7 | 168.3 |
| 2 | 41.6 ± 8.3 | 736.6 ± 0.1 | 804.6 ± 0.08 | 17.7 | 19.3 |
| 3 | 800 ± 0 | 1,595.4 ± 0.4 | 1,608.8 ± 0.03 | 1.99 | 2.01 |
| 4 | 1,360 ± 16.6 | 747.4 ± 0.3 | ND | 0.55 | ND |
| HePC | 3.38 ± 0 | 128.1 ± 0.3 | 146.1 ± 0.03 | 37.9 | 43.2 |
a
Each concentration (serial dilutions) was tested in triplicate in three independent experiments. IC50, 50% inhibitory concentration; CC50, cytotoxic concentration; HMØ; blood-derived human macrophages; ND, not determined.