TABLE 2.
Effects of GF on parameters of overall renal function in GM-induced nephrotoxicity
| Parameter | Value (mean ± SEM) for groupa |
|||||
|---|---|---|---|---|---|---|
| CT | GM | CT-GF (25 mg/kg) | GM+GF (6.25 mg/kg) | GM+GF (12.5 mg/kg) | GM+GF (25 mg/kg) | |
| Serum creatinine (mg/dl) | 0.62 ± 0.03 | 1.05 ± 0.08* | 0.51 ± 0.01# | 0.87 ± 0.06 | 0.78 ± 0.07# | 0.63 ± 0.03# |
| Creatinine clearance (ml/min) | 1.02 ± 0.18 | 0.41 ± 0.08* | 0.97 ± 0.1# | 0.55 ± 0.08 | 0.68 ± 0.09 | 0.88 ± 0.14# |
| Urea (mg/dl) | 47.3 ± 2.61 | 80.6 ± 7.77* | 37.9 ± 2.8# | 62.5 ± 6.7 | 53.8 ± 6.9# | 41.7 ± 1.8# |
| Urinary protein (mg/dl) | 40.5 ± 4.48 | 93.5 ± 9.28* | 44.5 ± 4.82# | 78.3 ± 9.93 | 55.6 ± 7.74# | 51.3 ± 3.24# |
| Uric acid (mg/dl) | 1.33 ± 0.21 | 3.74 ± 0.52* | 1.57 ± 0.29# | 2.5 ± 0.5 | 2.33 ± 0.71 | 1.66 ± 0.33# |
a
*, statistically significant (P < 0.05) compared to control (CT); #, statistically significant (P < 0.05) compared to GM.